Working Groups

LEADERS

The interaction mechanisms of plasma with biological systems are not trivial, due to the complexity of both plasmas and the biological target. Therefore, unification of all the known physical and biochemical mechanisms will allow for the advancement towards a general vision and a better understanding of plasma technology in biomedical applications. Besides, different plasma sources have been licensed as medical devices and are already in use in hospitals and healthcare centers for treating patients affected by different dermatological diseases (diabetic wounds, infected wounds, burns, etc.). There’s a need for a deep and systematic recollection of data emerging from CAP treatment of biological substrates in-vivo, with a special interest in the standardization of physical/chemical measurements related to such interaction. This task will address this issue by surveying different CAP sources available on the market worldwide, with a deep characterization of their physical principle of operation and related effect in the specific field of application.

LEADERS

Plasma decontamination is a promising technique for the treatment of medical devices and implants, as well as for the healing of chronic wounds associating infection, or in decontamination of bucodental cavity. While many mechanisms involved in plasma-driven decontamination have been uncovered, there is still room for deeper investigations, especially when dealing with plasma-treated liquids. Bacteria and related biofilms or spores have been the object of most plasma-decontamination-related studies. In the current COVID‐19 pandemic new CAP assisted preventive solutions are envisaged, to mitigate the effects of airborne transmission of SARS‐CoV‐2 in poorly ventilated spaces through aerosol microdroplets, which can remain in the air for long periods and can be transmitted to others over distances >1 m. Tasks in this WG will be directed towards a better understanding of the role of plasma in decontamination processes and developing standard plasma treatment protocols for antimicrobial applications.

LEADERS

This WG will study the role of plasma on the regeneration of different tissues, namely skin in views on wound disinfection, stimulation of wound healing, but also on regenerative processes which are of great interest for the cosmetics industry. In both cases, there is evidence that plasma treatment can be efficacious, but the biological mechanisms involved in these processes are uncertain. In this context, there are concerns about safety, so it is necessary to have a better understanding of the molecular and cellular effects such as the implications of plasma stimulation of cell regeneration. Besides, other tissues are of great interest and research is starting to focus, for instance: mucosae, and cartilaginous and bone tissues. This knowledge may be critical to the clinical success of this type of therapy, to find suitable treatments providing beneficial effects and avoiding damage. 

LEADERS

This WG will focus on CAP and PTL treatments for cancer therapy. This novel therapeutic approach is based on the ability of plasma treatment to kill tumor cells without affecting the healthy cells within the surrounding tissues. It has been demonstrated that indirect treatment using plasma-treated liquids (mainly containing long-lived RONS) exerts very similar effects compared to direct plasma treatment (that contains also short-lived RONS, radiations and electromagnetic fields). In this sense, plasma generated long-lived RONS are thought to be among the major contributors in selectively killing cancer cells. Therefore, based on this fundamental insight, this Action will take particular attention to studying the field of redox biology to explain and understand the molecular basis behind the biological effects of plasma in cancer treatment. 

LEADERS

Both for tissue regeneration, skin treatment, wound healing as well as for cancer treatment, in complex cases, the use of plasma alone may not be sufficient to achieve full patient recovery, so investigation of combination therapies with ie. low doses of drugs may be an important asset. 

LEADERS

This WG will consolidate the multidisciplinary network actively involved in plasma medicine to facilitate scientific knowledge exchange through conferences, e-learning, video materials, seminars and training schools. It will build capacity, entrepreneurial programs, and encourage mobility for young scientists. All participants of the Action will be involved in this WG. Activities will include brainstorming, transfer of knowledge, capacity building and development of the entrepreneurial program (s) and mobility. The WG will organize workshops, training schools, conferences, online seminars, STSM, web page with member area to share confidential materials, & social media (twitter/Instagram). The special focus will be on participants coming from ITC, PhD students and ECI.

You can find an updated list of Working Group members following this link.